In order to compare the effects of modified radical mastectomy(MRM) and partial mastectomy(RM), axillary lymph node dissection(AD) & radiotherapy(RT) on locoregional recurrence, overall survival and disease-free survival, a randomized clinical
study of
187 patients with T1, T2 breast cancer was performed. One hundred eighty seven patients with T1, T2 breast cancer, admitted at Yongdong Severance Hospital from April 1991 to August 1994, were randomized into two different treatemtn groups. Of the
187
patients, 111 patients had received MRM and 76 had received PM, AD & RT. In any of the variables considered, with the sole exception of age, such as tumor size, incidence of axillary lympg node metastasis, histologic grading, estrogen and
progesteron
receptor positive rate, no significant difference of patient characteristics between the two groups was found(p>0.05). Using the Kaplan-Meier Product-limit method and log, rank test, the differences of loccregional recurrence, overall and
disease-free
survival, between these comparable groups were analyzed. Three out of 111 MRM patients and two out of 76 PM, AD & RT patients had locoregional recurrence. The overall survival rates in MRM and PM, AD & RT patients were, respectively, 93.7% and
94.1%.
Furthermore, the disease-free survival rates were, respectively, 89.2% and 93.9%. This result indicates that there was no significant difference between two groups in locoregional recurrence, overall and disease-free survival. Having gained a
better
cosmetic appearance, the conservative treatment group was satisfied with the PM, AD & RT. In this study, we conclude that PM, AD & RT is a good alternative surgical treatment modality for T1, T2 Korean breast cancer patients, which could
substitute
the
more traditional MRM.
However, further follow-up period will be needed for long term results.
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